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Even medications can cause a deficiency, which is why its important to only take those you absolutely need and have been prescribed by a physician

Adeno-associated virus infection Adeno-associated virus serotype 6 (AAV6) encoding mature BDNF with an N-terminal fusion albumin signal peptide sequence under the control of the epithelial-specific surfactant protein C (SPC) promoter (AAV6-SPC-BDNF) and negative control (AAV6-SPC-NC) were obtained from Genechem (Shanghai, China)

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Semin Cell Dev Biol 116:9097

Indeed, exposure of tumor cells to elevated, yet physiologically relevant, pressure, using a pressurized cultured system that maintains a constant pH, has been found to increase or decrease cell proliferation, depending on the cancer cell type [51]

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